Start conservative — lower FOV, higher smoothness
There is no magic number that guarantees safety, but conservative settings survive longer. Most staff recommendations start around a narrow FOV band and smoothness high enough that crosshair movement looks like tracking, not snapping. If spectators can see your crosshair teleport, you are already past what Blizzard Anti-Cheat and human review tolerate.
Use separate profiles for hitscan and projectile heroes. A Widow flick profile should not be the same as a Tracer tracking profile. Overwatch 2 Cheats supports per-hero slots — use them instead of one global rage config.